The hospital is situated at the corner of Dorpsig & Van Riebeeck Streets in Bredasdorp, Western Cape. Nearby main roads are the R316 to the North and the R319 to the North-East of the hospital. Bredasdorp is located 71km South-West of Swellendam and 90km East of Hermanus in the Western Cape.
Otto Du Plessis hospital is a public hospital and therefore services are free to pregnant and breastfeeding women, as well as children under the age of six years old and pensioners. Other patients are charged a consultation and/or admission fee.