The hospital is situated at 4515 North Street in Barkly West, Northern Cape. Nearby main roads are the R31 and the R374 to the East of the hospital. Barkly West is located 38.2km North-West of Kimberley and 35.2km South-West of Windsorton.
Professor ZK Mathews Hospital is a public hospital and therefore services are free to pregnant and breastfeeding women, as well as children under the age of six years old and pensioners. Other patients are charged a consultation and/or admission fee.