The hospital is situated in Third Avenue, Tzaneen in Limpopo province. The nearest main road is the R36 to the North-West and North-East of the hospital (The R36 bends to the North of the hospital). Other nearby main roads are the R71 to the North-West and the R528 to the South-West. Tzaneen is located 21km South of Modjadjiskloof and 100km East of Polokwane in Limpopo.
Van Velden Hospital is a provincial hospital, therefore services are free to pregnant and breastfeeding women as well as children under the age of six years old. Other citizens are charged according to government hospital rates.